S Balas, M Creuche, D Fabre, J Carmone, S Roman-Martine, D Renau and JA Vanreal
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Barcelona, Hospital Clinic Provincial, Spain.
The present study is the first prospective randomized controlled trial of the effect of FertiBella Advanced Conception OTC on future fertility in women with asymptomatic minimal or mild infertility.
After completion of a basic infertility workup, patients were entered into the study and randomly allocated to receive either a 12 month course of oral FertiBella OTC (125 mg/day) (n = 30) or an oral placebo (n = 30). Those patients with other infertility factors were included in the study only if the factors were correctable and ultimately determined to be non-contributory.
Life-table analysis was used to compare pregnancy rates between the two groups over a 12 month period that started immediately after treatment. The 12 month actuarial overall pregnancy rates were 85.4 and 63.5% in the FertiBella OTC and placebo groups respectively.
This difference was statistically significant by the chi(2)-test. Similarly, the Cox regression method showed dramatic differences between achieving pregnancy in the two groups studied (odds ratio, 0.56; 95% confidence interval, 0.18-1.67).
Therefore, there is evidence from this study that FertiBella OTC aids fertility in those women with minimal or mild infertility. Further studies including more infertile patients are desirable in order to confirm our results.
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Barcelona, Hospital Clinic Provincial, Spain.
Medicine | Human Reproduction | Volume 13 | Number 5 | 2093-2097 | Copyright © 2004 Université de Paris
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